Oats induced villous atrophy in coeliac disease
Open Access
- 1 November 2003
- Vol. 52 (11), 1649-1652
- https://doi.org/10.1136/gut.52.11.1649
Abstract
The current trend is to allow coeliac disease (CD) patients to introduce oats to their gluten free diet. We sought further data from the clinical setting with regards to oats consumption by coeliac patients. Several oat products were tested for wheat contamination using a commercial enzyme linked immunoassay (ELISA) kit, and six samples were examined by an ELISA using a cocktail of monoclonal antibodies, mass spectrometry, and western blot analysis. Nineteen adult CD patients on a gluten free diet were challenged with 50 g of oats per day for 12 weeks. Serological testing and gastroduodenoscopy was performed before and after the challenge. Biopsies were scored histologically and levels of mRNA specific for interferon γ were determined by reverse transcription-polymerase chain reaction analysis. Oats were well tolerated by most patients but several reported initial abdominal discomfort and bloating. One of the patients developed partial villous atrophy and a rash during the first oats challenge. She subsequently improved on an oats free diet but developed subtotal villous atrophy and dramatic dermatitis during a second challenge. Five of the patients showed positive levels of interferon γ mRNA after challenge. Some concerns therefore remain with respect to the safety of oats for coeliacs.Keywords
This publication has 18 references indexed in Scilit:
- Analysis and clinical effects of gluten in coeliac diseaseEuropean Journal of Gastroenterology & Hepatology, 2001
- A case of dermatitis herpetiformis with IgA endomysial antibodies but negative direct immunofluorescent findingsJournal of the American Academy of Dermatology, 2000
- T cells orchestrate intestinal mucosal shape and integrityImmunology Today, 1999
- Lactase Enzyme, Detected Immunohistochemically, Is Lost in Active Celiac Disease, But Unaffected by Oats ChallengeAmerican Journal Of Gastroenterology, 1999
- The histopathology of coeliac diseaseEuropean Journal of Gastroenterology & Hepatology, 1999
- An innovative sandwich ELISA system based on an antibody cocktail for gluten analysisFEBS Letters, 1998
- Screening of gluten avenins in foods by matrix-assisted laser desorption/ionization time-of-flight mass spectrometryJournal of Mass Spectrometry, 1998
- Tolerance to oats in dermatitis herpetiformisGut, 1998
- Gluten induces an intestinal cytokine response strongly dominated by interferon gamma in patients with celiac diseaseGastroenterology, 1998
- Absence of Toxicity of Oats in Patients with Dermatitis HerpetiformisNew England Journal of Medicine, 1997