The value of narrowband imaging using the Ni classification in the diagnosis of laryngeal cancer
Open Access
- 26 June 2020
- journal article
- research article
- Published by Wiley in Laryngoscope Investigative Otolaryngology
- Vol. 5 (4), 665-671
- https://doi.org/10.1002/lio2.414
Abstract
Introduction: Narrowband imaging (NBI) is a special endoscopic optical enhancement setting allowing better visualization of mucosal microvasculature compared to white light endoscopy. This study evaluates the validity of NBI using the Ni classification in the detection and differentiation of severe dysplasia (SD) and glottic squamous cell carcinoma (SCC).Methods: Patients with suspicious vocal cord lesions underwent conventional white light endoscopy followed by clinically indicated biopsy. At the same time, NBI images were obtained and graded independently. Lesions were graded from I to V according to the Ni classification and compared to histopathological findings.Results: Fifty‐two patients were included in this study (40 SCC and 12 SD). The sensitivity and specificity of NBI in diagnosing laryngeal cancer was 95.0% (CI, 83.9%‐99.4%) and 83.3% (CI, 51.6%‐97.9%), respectively. The negative likelihood ratio was 0.06. Higher Ni grades correlated very strongly with more advanced disease.Conclusions: NBI using the Ni classification is a sensitive diagnostic tool for the detection and differentiation of early neoplastic and preneoplastic glottic lesions. As higher Ni classification correlates strongly with advanced disease, it serves as a useful adjunct to white light endoscopy in the diagnosis of laryngeal cancer.Level of Evidence: Level IV.Keywords
This publication has 42 references indexed in Scilit:
- Effectiveness of narrow band imaging in the detection of premalignant and malignant lesions of the larynx: Validation of a new endoscopic clinical classificationHead & Neck, 2014
- Retrospective Analysis of Prognostic Factors in 205 Patients with Laryngeal Squamous Cell Carcinoma Who Underwent Surgical TreatmentPLOS ONE, 2013
- Narrow band imaging in endoscopic evaluation of the larynxCurrent Opinion in Otolaryngology & Head and Neck Surgery, 2012
- High specificity of combined narrow band imaging and autofluorescence mucosal assessment of patients with head and neck cancerHead & Neck, 2012
- Endoscopic diagnosis of laryngeal cancer and precancerous lesions by narrow band imagingThe Journal of Laryngology & Otology, 2010
- Early Detection of Superficial Squamous Cell Carcinoma in the Head and Neck Region and Esophagus by Narrow Band Imaging: A Multicenter Randomized Controlled TrialJournal of Clinical Oncology, 2010
- Detecting early oral cancer: narrowband imaging system observation of the oral mucosa microvasculatureInternational Journal of Oral & Maxillofacial Surgery, 2010
- The angiogenic switch in carcinogenesisSeminars in Cancer Biology, 2009
- Five-Year Survival Rates and Time Trends of Laryngeal Cancer in the US PopulationJAMA Otolaryngology–Head & Neck Surgery, 2008
- NARROW‐BAND IMAGING COMBINED WITH MAGNIFIED ENDOSCOPY FOR CANCER AT THE HEAD AND NECK REGIONDigestive Endoscopy, 2005