Learning from the worm: the effectiveness of protein-bound Moco to treat Moco deficiency
Open Access
- 1 February 2021
- journal article
- research article
- Published by Cold Spring Harbor Laboratory in Genes & Development
- Vol. 35 (3-4), 177-179
- https://doi.org/10.1101/gad.348176.120
Abstract
Molybdenum cofactor (Moco) is synthesized endogenously in humans and is essential for human development. Supplementation of Moco or its precursors has been explored as a therapy to treat Moco-deficient patients but with significant limitations. By using the nematode C. elegans as a model, Warnhoff and colleagues (pp. 212–217) describe the beneficial impact of protein-bound Moco supplementation to treat Moco deficiency. If such an effect is conserved, this advance from basic research in worms may have significant clinical implications as a novel therapy for molybdenum cofactor deficiency.Keywords
Funding Information
- National Institutes of Health (R35GM139631, R01AR074503, R01GM047869)
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