Pantothenic Acid Deficiency Induced in Human Subjects.

Abstract

An abnormal metabolic state was induced in 4 human volunteers through combined use of a diet deficient in pantothenic acid and a metabolic antagonist, (omega-methyl pantothenic acid). This was accompanied by clinical and biochemical abnormalities suggesting adrenal cortical insufficiency, and by a peripheral neuropathy. Administration of pantothenic acid alone did not immediately reverse the abnormal state. A good diet of natural foods and multiple vitamins resulted in rapid complete recovery.