Isoproterenol induced myocardial necrosis is associated with stress protein synthesis in rat heart and thoracic aorta
- 1 July 1986
- journal article
- research article
- Published by Oxford University Press (OUP) in Cardiovascular Research
- Vol. 20 (7), 512-515
- https://doi.org/10.1093/cvr/20.7.512
Abstract
Large doses of isoproterenol, which produced macroscopically visible myocardial necrosis, induced the synthesis and accumulation of a 71 000 dalton protein (SP71) in the heart, aorta, and salivary gland of adult male rats. This protein was identical to a protein that has previously been found to be synthesised in the heart in response to heat shock and tissue slicing. Detectable amounts of SP71 were no longer seen five days after the isoproterenol injection, suggesting that this protein accumulates as part of a cellular response to stress and then degrades during tissue repair.Keywords
This publication has 12 references indexed in Scilit:
- lon gene product of Escherichia coli is a heat-shock proteinJournal of Bacteriology, 1984
- Thermolability of ubiquitin-activating enzyme from the mammalian cell cycle mutant ts85Cell, 1984
- AppppA, heat-shock stress, and cell oxidation.Proceedings of the National Academy of Sciences, 1983
- Characterization of the synthesis and accumulation of a 71-kilodalton protein induced in rat tissues after hyperthermiaCanadian Journal of Biochemistry and Cell Biology, 1983
- Diverse forms of stress lead to new patterns of gene expression through a common and essential metabolic pathway.Proceedings of the National Academy of Sciences, 1982
- Trauma-Induced Protein in Rat Tissues: A Physiological Role for a "Heat Shock" Protein?Science, 1981
- Differences in protein synthesized in vivo and in vitro by cells associated with the cerebral microvasculature. A protein synthesized in response to trauma?Neuroscience, 1980
- Cultured animal cells exposed to amino acid analogues or puromycin rapidly synthesize several polypeptidesJournal of Cellular Physiology, 1980
- Excessive Stimulation of Salivary Gland Growth by IsoproterenolScience, 1961
- AN INFARCT-LIKE MYOCARDIAL LESION AND OTHER TOXIC MANIFESTATIONS PRODUCED BY ISOPROTERENOL IN THE RAT1959