Reactions with Aziridines; 351. α-Aryl-γ-amidobutyric Acids (N-Protected α-Aryl-GABAs) by Amidoethylation of Dianions of α-Arylacetic Acids

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Abstract
Disodium enediolates of substituted acetic acids react with N-acylaziridines to yield the novel α-substituted γ-amidobutyric acids provided that the acid carries an aryl substituent in the α-position.