INVITRO INDUCTION OF ORNITHINE DECARBOXYLASE IN URINARY-BLADDER CARCINOMA-CELLS
- 1 January 1981
- journal article
- research article
- Vol. 41 (2), 405-409
Abstract
The induction of ornithine decarboxylase by normal rat urine in bladder cancer cell cultures was tested in view of recent observations that urine acts as a tumor promoter. Addition of urine up to 15% in final concentration to culture medium resulted in a 10-fold increase in ornithine decarboxylase activity over the control. The stimulatory factor(s) contained in urine appears heat stable and may be multiple. 12-O-Tetradecanoylphorbol-13-acetate, a potent promoter in mouse skin carcinogenesis, induced a 39-fold increase in ornithine decarboxylase activity, the best response among the various substances tested. This suggests that it may act as a promoter of bladder cancer.This publication has 15 references indexed in Scilit:
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