Mechanisms of chemical mutagenesis and carcinogenesis: effects on DNA replication of methylation at the O6-guanine position of dGTP
- 1 January 1983
- journal article
- research article
- Published by Oxford University Press (OUP) in Carcinogenesis: Integrative Cancer Research
- Vol. 4 (12), 1591-1597
- https://doi.org/10.1093/carcin/4.12.1591
Abstract
The incorporation of O6-methyl-dGTP during DNA replication in vitro by Klenow Escherichia coli pol I was determined. O6-Methyl-dGTP was found to: incorporate opposite T and C template residues, with a > 20-fold preference for T, and arrest DNA synthesis when incorporated in place of dATP at all but pyrimidine-rich growing-strand sequences. The significance of O6-methyl-dGTP incorporation during DNA biosynthesis in vivo for mutagenesis and carcinogenesis is discussed.This publication has 14 references indexed in Scilit:
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