Enzyme Activities and Extrinsic Proteins in Plasma Membranes From Normal Liver and Morris Hepatoma 5123tc 2

Abstract

Considerable specific activities for 5′-nucleotidase and Na⁺-K⁺-ATPase were in plasma membranes from normal liver and the lipoprotein subunits isolated from them. This suggested a high degree of metabolism involving the substrates and end products of these enzymes. The specific and relative specific activities of these important enzymes were greatly diminished in membranes from the Morris hepatoma 5123tc; this indicated that certain metabolic processes did not function at a normal level in these plasma membranes.