SUGARS AND HISTAMINE-INDUCED CAPILLARY LEAKAGE

Abstract

Capillary leakage of intravenous Evans blue (2% w/v in saline, 0.3 ml per 100 g of rat, 12 hours fasted) was produced by intradermal injections of 0.01 and 0.02 μmoles of histamine in 0.1 ml solution. The leakage was inhibited by topical D-glucose at a histamine to glucose molar ratio of 1:16. Topical sucrose inhibited at a ratio of 1:2 and D- and L-arabinose at 1:32. Higher or lower ratios of the sugars as well as equimolar urea or sodium chloride exerted no significant inhibition. Systemic administration of D-glucose (2, 4, 8 mmoles in 2 ml per 100 g body weight per os), that resulted in hyperglycemias of more than 120 mg/100 ml, also inhibited the histamine-induced capillary leakage.