2-Deoxy-D-glucose (2-DG) was injected intravenously (300 mg/kg) into 6 conscious monkeys adapted to chronic restraint in primate chairs. In 10 experiments, chow and water were provided to the monkeys after the injection of 2-DG. In 16 experiments, chow and water were withheld. Feeding did not affect themarked hyperglycemia or the increase in plasma growth hormone or 17-hydroxycorticosteroids elicited by 2-DG, but feeding markedly increased plasma immunoreactive insulin (IRI) concentrations, probably through the release of enteric stimulant(s) of insulin secretion. (Endocrinology85: 963, 1969)