THE EFFECT OF ADRENAL CORTICAL HORMONE ON THE SYNTHESIS OF CARBOHYDRATE IN LIVER SLICES

Abstract

In rat liver slice, adrenal cortical hormone increased the synthesis of carbohydrate from pyruvate or d-lactate but not from d-1-alanine or d-glutamate. Following a 24-hr. fast the total carbohydrate content of the liver of adrenalectomized rats was lower than that of normals. The total carbohydrate content of the liver of normal 24-hr.-fasted rats was increased significantly within 1 hr. after the intraperit. inj. of 5 ml. of adrenal cortical extract. In several instances changes in O2 consumption of rat liver slices following adrenal hormone therapy did not parallel the changes which were observed in the rate of carbohydrate synthesis.