Synchronous DNA synthesis and mitosis in multinucleate cells with one chromosome in each nucleus
- 1 March 1984
- journal article
- research article
- Published by Springer Nature in Chromosoma
- Vol. 89 (3), 197-200
- https://doi.org/10.1007/bf00294999
Abstract
Multinucleate cells were induced by colcemid treatment in PtK1 cells in culture. DNA synthesis and mitotic behavior of those cells in which each nucleus contained a single chromosome were studied. More than 80% of such cells showed synchronous DNA synthesis and mitosis in all nuclei. As these genetically different nuclei respond identically to the molecules that initiate DNA synthesis and mitosis, intranuclear control of initiation of DNA synthesis and induction of mitosis by genes on individual chromosomes can be excluded. The occasional occurrence of asynchronous division in multinucleate cells is assumed to result from unequal availability of the inducer molecules to the individual nuclei.Keywords
This publication has 22 references indexed in Scilit:
- CONTROL OF THE INITIATION OF DNA SYNTHESIS IN MAMMALIAN CELLSAnnals of the New York Academy of Sciences, 1982
- Multinucleate plant cells *1II. Requirements for nuclear DNA synthesisExperimental Cell Research, 1982
- REGULATION OF INITIATION OF DNA REPLICATIONAnnual Review of Genetics, 1979
- Mitosis in flat PTK2-human hybrid cellsExperimental Cell Research, 1979
- A Possible Role for Histone in the Synthesis of DNANature, 1972
- NUCLEO‐CYTOPLASMIC INTERACTIONS IN THE ACHIEVEMENT OF NUCLEAR SYNCHRONY IN DNA SYNTHESIS AND MITOSIS IN MULTINUCLEATE CELLSBiological Reviews, 1971
- ASYNCHRONY OF NUCLEAR DEVELOPMENT IN CYTOCHALASIN-INDUCED MULTINUCLEATE CELLSThe Journal of cell biology, 1969
- A low-viscosity epoxy resin embedding medium for electron microscopyJournal of Ultrastructure Research, 1969
- CHROMOSOME PULVERIZATION IN HUMAN BINUCLEATE CELLS FOLLOWING COLCEMID TREATMENTThe Journal of cell biology, 1967
- Synthetic activities leading to mitosisJournal of Cellular and Comparative Physiology, 1963