Lack of Tolerance to Δ 9 -Tetrahydrocannabinol in Chimpanzees
- 2 February 1973
- journal article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 179 (4072), 490-492
- https://doi.org/10.1126/science.179.4072.490
Abstract
Five chimpanzees were given Δ9-tetrahydrocannabinol (Δ9THC): 1.0 milligram per kilogram of body weight for 21 days and 4.0 milligrams per kilogram of body weight for 42 days. Although accuracy and speed of performance on a delayed matching-to-sample task were significantly affected by both doses, tolerance to Δ9THC did not develop. No long-term behavioral effects of Δ9THC were observed after termination of the drug regimens.Keywords
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