Relation between work output of respiratory muscles and end-tidal CO2 tension
- 1 May 1963
- journal article
- research article
- Published by American Physiological Society in Journal of Applied Physiology
- Vol. 18 (3), 497-504
- https://doi.org/10.1152/jappl.1963.18.3.497
Abstract
End-tidal CO2 tension, pulmonary ventilation, and work output of respiratory muscles were determined in six normal subjects breathing various mixtures of carbon dioxide in air, with three graded resistances added to both inspiration and expiration. In two individuals, the resistances were also added separately to inspiration or expiration. A linear relationship was found between work output of inspiratory muscles and end-tidal CO2 tension; this relationship was uninfluenced by added resistance. No consistent relationship was observed between either ventilation or work output of expiratory muscles and end-tidal CO2 tension. These results suggest that carbon dioxide controls directly the activity of inspiratory muscles alone and that the activity of expiratory muscles is only coincidentally involved. The possible role of intrinsic properties of respiratory muscles and of nervous mediation in the control of breathing is discussed. Submitted on October 22, 1962This publication has 17 references indexed in Scilit:
- THE RESPIRATORY RESPONSE TO CARBON DIOXIDE IN HEALTH AND IN EMPHYSEMAJCI Insight, 1960
- Measurement of Endoesophageal PressureJournal of Applied Physiology, 1958
- Respiratory Pattern and Respiratory Response to CO2Journal of Applied Physiology, 1958
- Effects of Graded Resistance to Tracheal Air Flow in ManJournal of Applied Physiology, 1957
- THE EFFECT OF OBSTRUCTION TO BREATHING ON THE VENTILATORY RESPONSE TO CO21JCI Insight, 1956
- The Work of BreathingPhysiological Reviews, 1954
- ON PROPRIOCEPTIVE RESPIRATORY REFLEXES1953
- Mechanics of Breathing in ManJournal of Applied Physiology, 1950
- THE RESPIRATORY RESPONSE TO CARBON DIOXIDE AND ANOXIA IN EMPHYSEMA1949
- Muscular force at different speeds of shorteningThe Journal of Physiology, 1935