Experimental cerebral ischemia in Mongolian gerbils
- 1 March 1976
- journal article
- research article
- Published by Springer Nature in Acta Neuropathologica
- Vol. 36 (1), 1-8
- https://doi.org/10.1007/bf00685142
Abstract
Behaviour of biogenic amines was studied in the brains of Mongolian gerbils subjected to unilateral occlusion of the common carotid artery. Assays on the hemispheres ipsilateral to occlusion revealed in symptom-positive animals a progressive decrease in norepinephrine and dopamine, and an increase in serotonin throughout the duration of an ischemic insult. In post-ischemic periods following the release of the clip, changes in biogenic amine levels generally conformed to the principles of a previously described “maturation” phenomenon, with delayed reactions occurring after the shorter ischemic insults.Keywords
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