Detailed structural analysis of exposed domains of membrane‐bound Na+, K+‐ATPase A model of transmembrane arrangement
- 15 June 1987
- journal article
- Published by Wiley in FEBS Letters
- Vol. 217 (2), 269-274
- https://doi.org/10.1016/0014-5793(87)80676-2
Abstract
Exposed regions of the α- and β-subunits of membrane-bound Na+,K+-ATPase were in turn hydrolyzed with trypsin. Resistance of the β-subunit to proteolysis was shown to be due mainly to the presence of disulfide bridge(s) in the molecule. A model for the spatial organisation of the enzyme in the membrane was proposed on the basis of detailed structural analysis of extramembrane regions of both subunits.Keywords
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