Purine Phosphoribosyltransferase in Gilles de la Tourette Syndrome

Abstract

Gilles de la Tourette syndrome is a neurologic disorder in which there are both motor and behavioral abnormalities, approximately 75 per cent of the patients are male and the onset of the disease is usually between two and 14 years of age.^{1 , 2} Recently, a genetic origin has been suggested on the basis of an approximate 10 per cent family history of the disease,^{2 , 3} with numerous reports describing both parent and offspring with the syndrome^{4 , 5} and a high rate in Ashkenazic Jews and a low rate in the black population. The initial symptom is usually involuntary ticlike muscle movements. With progression . . .