Familial Hypoparathyroidism with Pernicious Anemia, Steatorrhea and Adrenocortical Insufficiency

Abstract

IDIOPATHIC hypoparathyroidism is an uncommon condition,¹ but its association with impaired adrenal or gastrointestinal function and moniliasis has engendered interest in its pathogenesis.^{2 , 3} Three siblings were affected in the family described by Sutphin, Albright and McCune.⁴ The coexistence of hypoparathyroidism and pernicious anemia has been reported by Reisner and Ellsworth⁵ and Wilkins.⁶ In the family reported below, 5 out of 11 siblings were affected. The hypoparathyroidism was associated with impaired vitamin B₁₂ absorption in 4, impaired adrenal function in 2 and inconstant steatorrhea in 1. All 5 had partial anodontia and elevated sweat electrolyte concentrations. Four were mentally deficient. . . .