Three cases in which extravasation of spermatozoa in the wall of the vas deferens occurred, accompanied by formation of epithelial-lined spaces within the wall, are reported. All of the patients previously had undergone vasectomies. Review of the literature reveals several cases with similar lesions but different names. The author suggests that the lesions be designated “vasitis nodosa,” partly because what apparently was the first case reported was described by that name and partly because of the resemblance to salpingitis isthmica nodosa. Obstruction may be the most significant factor in pathogenesis.