Absence of close linkage between benign hereditary chorea and the locus D4S10 (probe G8).
Open Access
- 1 March 1988
- journal article
- research article
- Published by BMJ in Journal of Medical Genetics
- Vol. 25 (3), 191-194
- https://doi.org/10.1136/jmg.25.3.191
Abstract
A genetic linkage study between benign hereditary chorea and the locus D4S10 using the DNA probe G8 has shown two recombinations in five small families. There were negative lod scores at recombination fractions that show conclusive evidence of linkage in 16 larger British Huntington's disease families. We suggest that although benign hereditary chorea and Huntington's disease may have some clinical similarities they are probably at two different loci.This publication has 16 references indexed in Scilit:
- Studies of a DNA marker (G8) genetically linked to Huntington disease in British familiesHuman Genetics, 1986
- Benign Hereditary Chorea–Response to SteroidsDevelopmental Medicine and Child Neurology, 1985
- Genetic linkage between Huntington's disease and the DNA polymorphism G8 in South Wales families.Journal of Medical Genetics, 1985
- Deletion of Huntington's disease-linked G8 (D4S10) locus in Wolf–Hirschhorn syndromeNature, 1985
- Huntington's Disease: Two Families with Differing Clinical Features Show Linkage to the G8 ProbeScience, 1985
- Report of the committee on the genetic constitution of chromosomes 3 and 4Cytogenetic and Genome Research, 1985
- Benign familial chorea: an association with intellectual impairment.Journal of Neurology, Neurosurgery & Psychiatry, 1984
- Benign (non-paroxysmal) familial chorea. Paediatric perspectives.Archives of Disease in Childhood, 1981
- Benign Hereditary Non-Progressive Chorea of Early Onset1– Clinical Genetics of the syndrome and report of a New FamilyNeuropediatrics, 1976
- Familial benign chorea with intention tremor: A clinical entityThe Journal of Pediatrics, 1967