SPECIFIC ESTROGEN-RECEPTOR BINDING AND BIOLOGICAL EFFECTS OF 16-ALPHA-IODOESTRADIOL ON HUMAN-BREAST CANCER-CELLS
- 1 January 1981
- journal article
- research article
- Vol. 41 (8), 3150-3154
Abstract
16.alpha.-lodoestradiol was evaluated as an estrogen in MCF-7 and ZR-75-1 human breast cancer cells. 16.alpha.-[125I]Iodoestradiol binds to equivalent numbers of specific estrogen receptors with a comparable binding affinity and similar sucrose density gradient behavior. 16.alpha.-Iodoestradiol translocates receptor sites to the nucleus and induces a full range of estrogenic effects including thymidine incorporation, cell growth and progesterone receptor. Because of its high specific activity, this compound may have unique applications on imaging of estrogen receptor-containing cells and specific receptor-mediated cytotoxicity.This publication has 17 references indexed in Scilit:
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