Evaluation of Histamine Release in Rats by Analysis of Urine
- 1 June 1955
- journal article
- research article
- Published by American Physiological Society in American Journal of Physiology-Legacy Content
- Vol. 181 (3), 484-486
- https://doi.org/10.1152/ajplegacy.1955.181.3.484
Abstract
A method is described for evaluating histamine release in rats by analysis of urinary histamine. It uses rats in which histamine-metabolizing enzymes have been inhibited and in which bacterial histamine formation has been suppressed. The anti-inflammatory properties of cortisone and Phenergan are not due to prevention of histamine release. The total histamine released from rat tissues by a dose of 2 [mu]g/g 48-80 is about 150-190 ug/100g body weight.Keywords
This publication has 4 references indexed in Scilit:
- DETERMINATION OF HISTAMINE AS AN ISOTOPIC DERIVATIVEJournal of Biological Chemistry, 1955
- Binding and Release of Radioactive Histamine in Intact RatsAmerican Journal of Physiology-Legacy Content, 1954
- Reduction of tissue histamine by compound 48/80The Journal of Physiology, 1953
- Effect of Epinephrine, Antihistaminics and Adrenergic Blockade on Egg White Edema in Adrenal Insufficient Rats.Experimental Biology and Medicine, 1949