Alzheimer‐associated presenilin‐2 confers increased sensitivity to poptosis in PC12 cells
- 11 November 1996
- journal article
- Published by Wiley in FEBS Letters
- Vol. 397 (1), 50-54
- https://doi.org/10.1016/s0014-5793(96)01142-8
Abstract
Presenilin-2 is a gene of unknown function recently identified based upon linkage with some forms of familial Alzheimer's disease. To investigate potential effects of PS-2 on cell viability, rat pheochromocytoma (PC12) cells were stably transfected with cDNA constructs encoding either full-length human PS-2 or, for comparison, mouse Bcl-xL. Overexpression of PS-2 conferred increased sensitivity to the apoptotic stimuli staurosporine and hydrogen peroxide. In contrast, Bcl-xL overexpression significantly reduced cell death induced by these stimuli. These results suggest that one function of PS-2 may involve modulation of cell viability.Keywords
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