Potassium channel structures

Abstract

The molecular basis of K channel function is universally conserved. K+ channels allow K flux and are essential for the generation of electric current across excitable membranes, K, channels are also the targets of various intracellular control mechanisms, such that the suboptimal regulation of channel function might be related to pathological conditions. Because of the fundamental role of K channels in controlling membrane excitability, a structural understanding of their function and regulation will provide a useful framework for understanding neuronal physiology. Many recent physiological and crystallographic studies have led to new insights into the workings of K+ channels.