Autoantibodies Against Axonal Neurofilaments in Patients with Kuru and Creutzfeldt-Jakob Disease
- 10 October 1980
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 210 (4466), 190-193
- https://doi.org/10.1126/science.6997994
Abstract
The serums of some patients with subacute spongiform encephalopathies contain an autoantibody in higher titer against a normal fibrillar protein within the axon of mature central neurons in culture. The morphological features of this neurofilament, as demonstrated by immunofluorescence and immunoperoxidase staining, and the partial characterization of the antibody are described. The detection of this hetero-specific autoantibody is the first evidence of an immune reaction in the spongiform encephalopathies.This publication has 16 references indexed in Scilit:
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