Role of Interleukin-18 in Host Defense against DisseminatedCandida albicansInfection
Open Access
- 1 June 2002
- journal article
- research article
- Published by American Society for Microbiology in Infection and Immunity
- Vol. 70 (6), 3284-3286
- https://doi.org/10.1128/iai.70.6.3284-3286.2002
Abstract
In mice injected intravenously withCandida albicans, administration of anti-interleukin-18 (IL-18) antibodies increased the yeast load in the kidneys. There was no effect on the organ load withCandidawhen gamma interferon (IFN-γ)-deficient mice were treated with anti-IL-18 antibodies, suggesting that the protective effect of IL-18 is mediated through endogenous IFN-γ.Keywords
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