Inhibition of isolation-induced aggressive behavior with GABA transaminase inhibitors
- 1 January 1979
- journal article
- research article
- Published by Springer Nature in Psychopharmacology
- Vol. 62 (1), 23-27
- https://doi.org/10.1007/bf00426030
Abstract
Administration of aminooxyacetic acid (AOAA) and γ-acetylenic GABA (GAG) resulted in a dose-dependent suppression of aggressive behavior and a concomitant increase in brain GABA. The increase in GABA levels persisted beyond the time when AOAA and GAG exerted an anti-aggressive effect. Brain GABA levels remained significantly elevated over controls for 120 h after a single injection of AOAA and 46 h after a single dose of GAG.Keywords
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