Distribution of 3-Methylglucose in Organs of Rat.

Abstract

Analysis of various organs following intravenous injection of 3-methylglucose in nephrecto-mized rats indicates an apparent volume of distribution of 35-37% of body weight. Liver and myocardial water equilibrates with plasma; in other tissues, including voluntary muscle, the rate of passage of 3-methylglucose is slow in both directions. Tissue water of the latter organs reaches only about 1/3 to 1/4 the plasma concentration and still contains small amounts of 3-methylglucose 24 or 48 hours after a single intravenous dose in intact animals.