Ultrastructural Effects of Recombinant Gamma-Interferon on Cultured Human Keratinocytes
- 1 January 1986
- journal article
- research article
- Published by Taylor & Francis in Ultrastructural Pathology
- Vol. 10 (1), 17-21
- https://doi.org/10.3109/01913128609015559
Abstract
To extend our initial observations that recombinant gamma-interferon (r γIFN) influences the growth and differentiation of normal cultured human keratinocytes, we studied the electron microscopic changes induced by r γIFN. Treatment of cultured human keratinocytes with 103 units/ml (7.1 nM) of r γIFN produced a shift toward an increasing percentage of attached cells that had a mature-type, differentiated appearance rather than a basal type of proliferating cell, as observed in control, untreated cultures. This report extends the number of cell types that can be influenced by r γIFN at the ultrastructural level and supports the notion that r γIFN can influence both growth and maturation of normal cultured human keratinocytes.Keywords
This publication has 5 references indexed in Scilit:
- Induction of the Synthesis of Triton-Soluble Proteins in Human Keratinocytes by Gamma InterferonJournal of Investigative Dermatology, 1985
- Recombinant Gamma Interferon Induces HLA-DR Expression on Cultured Human KeratinocytesJournal of Investigative Dermatology, 1984
- ANTIPROLIFERATIVE EFFECTS OF RECOMBINANT ALPHA-INTERFERONS AND GAMMA-INTERFERONS ON CULTURED HUMAN KERATINOCYTES1984
- Factors controlling the in Vitro growth pattern of human microvascular endothelial cellsJournal of Ultrastructure Research, 1983
- Effect of Vitamin A Acid on Homeostasis and Differentiation of Epidermal Cells Cultured on CollagenDermatology, 1983