Mechanisms of Anion and Cation Permeations in the Resting Membrane of a Barnacle Muscle Fiber
Open Access
- 1 April 1971
- journal article
- Published by Rockefeller University Press in The Journal of general physiology
- Vol. 57 (4), 408-434
- https://doi.org/10.1085/jgp.57.4.408
Abstract
The resting membrane of a barnacle muscle fiber is mostly permeable to cations in a solution of pH 7.7 whereas it becomes primarily permeable to anions if the pH is below 4.0. Mechanisms of ion permeation for various monovalent cations and anions were investigated at pH 7.7 and 3.9, respectively. Permeability ratios were obtained from the relationship between the membrane potential and the concentration of the test ions, and ionic conductances from current-voltage relations of the membrane. The permeability sequence for anions (SCN > I > NO(3) > Br > ClO(3) > Cl > BrO(3) > IO(3)) was different from the conductance sequence for anions (Br, Cl > ClO(3), NO(3) > SCN). In contrast, the permeability and conductance sequences were identical for cations (K > Rb > Cs > Na > Li). The results suggest that anion permeation is governed by membrane charges while cation permeation is via some electrically neutral mechanism.Keywords
This publication has 22 references indexed in Scilit:
- Antibiotic-mediated transport of alkali ions across lipid barriers.Proceedings of the National Academy of Sciences, 1967
- Interaction between Cations in Hydrophobic Solvent-Saturated Filters Containing Fixed Negative ChargesBiophysical Journal, 1966
- The Steady-State Properties of Ion Exchange Membranes with Fixed SitesBiophysical Journal, 1965
- The Effects of Various Ions on Resting and Spike Potentials of Barnacle Muscle FibersThe Journal of general physiology, 1964
- Neuromuscular physiology of giant muscle fibers of a barnacle, Balanus nubilus DarwinComparative Biochemistry and Physiology, 1963
- Evidence for Anion-Permselective Membrane in Crayfish Muscle Fibers and Its Possible Role in Excitation-Contraction CouplingThe Journal of general physiology, 1963
- Internal chloride concentration and chloride efflux of frog muscleThe Journal of Physiology, 1961
- The influence of potassium and chloride ions on the membrane potential of single muscle fibresThe Journal of Physiology, 1959
- Effect of nitrate and other anions on the membrane resistance of frog skeletal muscleThe Journal of Physiology, 1959
- Anion interaction in frog muscleThe Journal of Physiology, 1958