Ultraviolet-Mediated Cytotoxic Activity of Phenylheptatriyne From Bidens pilosa L.
- 2 January 1979
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of Natural Products
- Vol. 42 (1), 103-111
- https://doi.org/10.1021/np50001a005
Abstract
The tropical weed B. pilosa L. (Asteraceae) contains a number of polyacetylenes which are phototoxic to bacteria, fungi and human fibroblast cells in the presence of sunlight, artificial sources of long-wave UV light, or cool-white fluorescent light. The principle photoactive compound in the leaf, phenylheptatriyne, is present in the cuticle as well as in the underlying cells. Experiments with calf thymus DNA indicate that, unlike photoactive furanocoumarins, phenylheptatriyne does not form interstrand cross linkages with DNA in UV light.This publication has 3 references indexed in Scilit:
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- A Simple Microbiological Method for Demonstrating Phototoxic Compounds**From the Dermatology Division, Cornell University Medical College, New York, N.Y.Journal of Investigative Dermatology, 1965
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