Autosomal dominant Lewy body parkinsonism in a four‐generation family
- 1 January 1994
- journal article
- case report
- Published by Wiley in Annals of Neurology
- Vol. 35 (1), 59-64
- https://doi.org/10.1002/ana.410350110
Abstract
We report a family with autosomal dominant parkinsonism. The propositus developed parkinsonism at a relatively young age (45 years) and came to autopsy after a 6‐year illness. She had typical features of Parkinson's disease except for an absence of rest tremor, although this was present in other family members. A diagnosis of Lewy body parkinsonism was confirmed by neuropathological examination. Additional pathological features included the presence of cortical Lewy bodies and anti‐ubiquitin‐positive neurites in the cornu Ammonis 2 and 3 (CA2‐3) region of the hippocampus. This kindred is similar both clinically and pathologically to a few previously reported pedigrees, further strengthening recent evidence of a genetic etiology of some forms of Parkinson's disease.Keywords
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