Plasma Clearance of dl-β-H3-Norepinephrine in Normal Human Subjects and Patients with Essential Hypertension*
Open Access
- 1 October 1964
- journal article
- research article
- Published by American Society for Clinical Investigation in Journal of Clinical Investigation
- Vol. 43 (10), 2009-2015
- https://doi.org/10.1172/jci105075
Abstract
Five normal subjects and 5 patients with essential hypertension were infused with dl-[beta]-H3-norepinephrine (H3-NE) after which the plasma H3-NE levels were measured. Three hours after the conclusion of the infusions the plasma H3-NE clearances became exponential at rates uniformly more rapid in the hypertensive than in the normotensive subjects. There is an abnormality in the dynamics of norepinephrine metabolism in patients with essential hypertension. Tritium-labeled water is a normal catabolite of H3-NE.This publication has 24 references indexed in Scilit:
- Supersensitivity and subsensitivity to sympathomimetic amines.1963
- Dehydroxylation of norepinephrineBiochimica et Biophysica Acta, 1963
- ESSENTIAL HYPERTENSION AND INHERITANCE OF VASCULAR REACTIVITYThe Lancet, 1961
- Uptake of Tritium-Labeled Norepinephrine in Brain and Other Tissues of Cat in vitroScience, 1961
- Urinary excretion of catecholamines and their metabolites in pheochromocytomaAmerican Heart Journal, 1961
- EFFECT OF DRUGS ON UPTAKE AND METABOLISM OF H3-NOREPINEPHRINE1961
- Different Pools of Catecholamines Stored in the Adrenal MedullaActa Physiologica Scandinavica, 1960
- The physiological disposition of H3-epinephrine and its metabolite metanephrine.1959
- [Experimental studies on serpasil (reserpin) a new and very effective Rauwolfia alkaloid with analeptic effect].1953
- THE NATURE OF THE PERIPHERAL RESISTANCE IN ARTERIAL HYPERTENSION WITH SPECIAL REFERENCE TO THE VASOMOTOR SYSTEMJournal of Clinical Investigation, 1936