Gas Diffusion Technique for Measurement of Renal Blood Flow With Special Reference to the Intact, Anuric Subject

Abstract

A gas diffusion method, using nitrous oxide, has been proposed as a method for the measurement of renal blood flow, particularly for clinical application to the anuric patient in whom such a measurement has not previously been possible. The general theory of such a method and a technic for its appln. to the renal circulation are described. This method was compared under varying exptl. circumstances with a standard reference of flow, the bubble flow meter, and a close correlation was obtained. For 17 clearance periods the mean difference was 0.01, the S. D. was 0.068, and the t value was 0.6.