The Management of Chronic Behavior Disorders in Mentally Retarded Adults with Lithium Carbonate

Abstract

The medical literature was reviewed and 2 case histories presented regarding the efficacy of lithium carbonate in the treatment of chronic behavior disorders in mentally retarded adults. The available data lend tentative support for the use of Li to manage behavior disorders in retarded individuals which are characterized by lifelong hyperactivity, aggressiveness and/or self-mutilation. It was recommended that, when Li is used for this indication, a blood level of .apprx. 1.0 meq/l is necessary and that all patients be given a drug-free trial once a therapeutic effect had been achieved to assess the continued need for treatment. Etiological issues, a possible mechanism of action involving Li effect on CNS serotonergic activity and areas for future research are discussed.