The antagonistic action of coffee and alcohol.

Abstract
With the dosages used, alcohol inhibits the parotid gland secretion, with the effect coming in waves which are still evident at the end of a five-hour period. When both coffee and alcohol are taken together, there is a characteristic antagonistic reation, and the secretion approximates normal for an hour after the coffee ingestion, after which time the coffee effect wears off and the alcohol inhibition is apparent again. Coffee has a slightly beneficial effect upon steadiness and motor coordination, whereas alcohol causes a disturbance. When taken together, there is an antagonistic reaction, with the coffee effect dominant, and steadiness and motor coordination remain practically normal. This effect lasts for at least an hour with a regular coffee user, and for two or more hours with the non-user. As the effects of the alcohol become more pronounced, the subject's movements become less differentiated and grosser, and soon the arm movements, which were formerly localized, become generalized into a body sway. (PsycINFO Database Record (c) 2006 APA, all rights reserved)