Some Biological Properties of a Urinary Norethynodrel Metabolite.
- 1 April 1965
- journal article
- research article
- Published by Frontiers Media SA in Experimental Biology and Medicine
- Vol. 118 (4), 862-865
- https://doi.org/10.3181/00379727-118-29991
Abstract
Summary Estrogenic activity of 17α-ethynyl-19-norandrost-4-ene-3β,10β,17β,-triol, a urinary metabolite of norethynodrel, was investigated. The compound exhibited slight estrogenicity when administered subcutaneously. Gavage resulted in increased estrogenicity. Within a limited dose range, injection of the compound together with estrone resulted in synergistic estrogenic activity.Keywords
This publication has 9 references indexed in Scilit:
- Studies on the Aromatization of 10β-Hydroxy-3-keto Steroids1Journal of Medicinal Chemistry, 1964
- The metabolic fate of orally administered 3H-norethynodrel and 3H-norethindrone in humansBiochemical Pharmacology, 1963
- Estrogen Antagonism: A Comparison of the Effects of Various Antiestrogens Administered Separately and as Mixtures with the EstrogenEndocrinology, 1963
- Metabolic Fate of Orally Administered H3-Norethynodrel in RabbitsEndocrinology, 1962
- Inherent Estrogenicity of Norethindrone and Norethynodrel: Comparison with Other Synthetic Progestins and Progesterone1Journal of Clinical Endocrinology & Metabolism, 1962
- MICRO-DETERMINATION OF CARBONIC ANHYDRASE ACTIVITY IN ANIMAL TISSUE1Endocrinology, 1960
- SOME BIOLOGICAL ACTIVITIES OF 17-ETHYNYL AND 17-ALKYL DERIVATIVES OF 17-HYDROXYESTRENONESAnnals of the New York Academy of Sciences, 1958
- SOME CHEMICAL AND BIOLOGICAL PROPERTIES OF 19-NOR-17?-ETHYNYLTESTOSTERONEAnnals of the New York Academy of Sciences, 1958
- PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENTJournal of Biological Chemistry, 1951