Stop-flow studies on renal handling of lithium ions in the dog

Abstract

Stop-flow experiments were performed on dogs after serum Li concentrations had been raised to 10–21 mEq/liter with intravenous infusions of Li salts. Li is actively reabsorbed at a distal portion of the nephron close to the site of sodium and potassium reabsorption. Li may cause alkalinization of the urine by inhibiting H⁺ secretion. Stimulation of K secretion by Li could not be demonstrated. Li may reduce K reabsorption.