Protection Against Syngeneic Tumor Grafts Induced by Inoculation with Normal allogeneic Tissues
- 1 January 1977
- journal article
- research article
- Published by Taylor & Francis in Immunological Communications
- Vol. 6 (6), 547-558
- https://doi.org/10.3109/08820137709093465
Abstract
Subcutaneous injection of normal allogeneic kidney and liver tissues extended survival of DBA/2Cr mice challenged with a lethal dose of syngeneic L5178Y lymphoma cells. Immunization with a combination of tissues from five strains provided far more protection than immunization with tissue from any single strain. It is suggested that the basis of this protective effect is a cross-reactivity or identity between tumor-associated transplantation antigens (TATA) on the L5178Y tumor and non-H-2 alloantigens normally expressed by some allogeneic tissues.Keywords
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