EFFECTS OF ANTIMICROTUBULAR AGENTS ON THE SECRETION OF COLLAGEN
Open Access
- 1 August 1974
- journal article
- Published by Rockefeller University Press in The Journal of cell biology
- Vol. 62 (2), 390-405
- https://doi.org/10.1083/jcb.62.2.390
Abstract
Embryonic chick cranial bone was cultured in the presence of the antimicrotubular agents, colchicine and vinblastine, and with a number of other compounds known from previous studies to affect the cellular handling of collagen. Secretion of procollagen, quantitated by light microscope autoradiography, was correlated with the extent of conversion of procollagen to collagen and with rates of collagen and noncollagen-protein synthesis.Keywords
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