THE HEMOPOIETIC EFFECT OF COBALT AND COBALT-MANGANESE COMPOUNDS IN RABBITS

Abstract

Subcut. injections of Co and Co-Mn compounds produced in rabbits hemopoiesis, shown by a high reticulo-cyte count, appearance of dividing normoblasts in the circulating blood, anisocytosis, polychromasia, the development of a eosinophilia, a transient lymphocytosis, a slight basophilia, and a slight lymphopoiesis. The addition of Mn to the Co heightens the erythropoietic effect of the cobalt by adding an erythremia. The combination of Co and Mn seems to be less toxic than equivalent stimulation with Co alone.