In 37 cases of gonadal dysgenesis (gonadal apasia) the dorsopalmar roentgenograms of the wrist and hand were taken in the neutral position, and abnormalities were found in the shape of the proximal carpal row. In order to obtain more precise data, 2 tangents were drawn, the first touching the proximal contour of navicular and lunate bones and the second touching the triquetral and lunate bones. The intersection of these tangents resulted in an angle called the carpal angle. From the measurements of this angle performed in 466 normal subjects, a mean value of 131.5° was obtained, while in all patients with gonadal dysgenesis the carpal angle was below the normal mean value. In addition, in half the patients with gonadal dysgenesis there was an abnormal angular shape of the proximal carpal row when the carpal angle was 117° or less; this was called the positive carpal sign. On roentgenograms of the wrist in control subjects the positive carpal sign was found in only 5.4%. Thus, the incidence of the positive carpal sign in gonadal dysgenesis was about 10 times as high as in normal subjects.