Acetylcholine and the Epileptiform Activity of Chronically Isolated Cortex
- 1 May 1971
- journal article
- research article
- Published by American Medical Association (AMA) in Archives of Neurology
- Vol. 24 (5), 401-408
- https://doi.org/10.1001/archneur.1971.00480350035003
Abstract
Solutions of acetylcholine were applied to the chronically isolated and the contralateral occipital cortex of cats prepared as encéphale isolé. The amounts required to produce epileptiform discharges were similar on the two sides. The spontaneous paroxysmal activity in the island was not facilitated by the application of acetylcholine but it disappeared before or at the onset of acetylcholine-induced discharges. Electrical stimulation revealed neither a decrease of the threshold for epileptiform afterdischarges nor a facilitation of spontaneous discharges on the isolated side. However, the seizure discharges in the isolated area, once induced by either acetylcholine or electrical stimulation, continued for long periods of time. The results suggest that acetylcholine acts as a convulsant stimulus without a special relationship to the intrinsic epileptiform abnormality of the isolated cortex.Keywords
This publication has 14 references indexed in Scilit:
- Influence of increased local cholinergic activity on discharge patterns of hippocampal FOCIElectroencephalography and Clinical Neurophysiology, 1970
- Acetylcholinesterase activity in partially isolated cerebral cortex after prolonged intermittent stimulationExperimental Neurology, 1968
- Cholinesterase activity of chronic partially isolated cortexNeurology, 1965
- Epileptiform Seizures From Chronic Isolated CortexArchives of Neurology, 1963
- Regional differences in the epileptiform electrical response of the unanesthetized cerebral cortex to acetylcholineNeurology, 1962
- The electrical excitability of chronically isolated cortex studied by means of permanently implanted electrodesElectroencephalography and Clinical Neurophysiology, 1962
- The supersensitivity of chronically “isolated” cerebral cortex as a mechanism in focal epilepsyElectroencephalography and Clinical Neurophysiology, 1959
- Some preliminary electrophysiological studies on chronic neuronally isolated cerebral cortexElectroencephalography and Clinical Neurophysiology, 1957
- ACETYLCHOLINE AND CONVULSIVE ACTIVITYJournal of Neurophysiology, 1949
- EFFECT OF CERTAIN CHOLINE DERIVATIVES ON ELECTRICAL ACTIVITY OF THE CORTEXArchives of Neurology & Psychiatry, 1942