147 liver biopsies were performed in 79 patients with severe psoriasis, 18 patients with Parkinson’s disease, and post mortem in 42 patients following sudden death from cardiac failure or traffic accident. 47 of the biopsies in psoriatics were performed prior to treatment with methotrexate. 40 biopsies were taken during treatment. A high incidence of pathological findings were found in both groups of psoriatics. Fatty metamorphosis, periportal inflammation, and focal necroses were found in statistically higher degree among psoriatics than among controls. It is suggested that besides being due to presence of obesity, drug exposure, and alcohol intake, liver pathology in psoriatics may be associated with the disease itself. No statistically significant differences were found between the two groups of biopsies from psoriatics.