Demonstration of a common major gene with pleiotropic effects on immunoglobulin E levels and allergy
- 1 January 1985
- journal article
- research article
- Published by Wiley in Genetic Epidemiology
- Vol. 2 (4), 327-338
- https://doi.org/10.1002/gepi.1370020402
Abstract
Atopic disease is generally recognized to be familial, although specific genetic components have yet to be identified. High levels of a unique class of immunoglobulins, immunoglobulin E (IgE), have been shown to be associated with allergies. Several investigators have reported evidence indicating a recessive regulatory locus where an individual with the homozygous recessive genotype has persistently elevated levels of IgE. Willcox and Marsh [1978] have proposed a hypothesis relating IgE production and liability to become allergic. A test of this hypothesis was carried out in the present study. Bivariate segregation analysis of IgE levels and allergy was performed on 173 nuclear families, and the results indicate that an IgE regulatory locus contributes to the familial transmission of allergy. The results are further discussed in the context of the Willcox and Marsh hypothesis.Keywords
This publication has 20 references indexed in Scilit:
- Inheritance of immunoglobulin E: Genetic model fittingAmerican Journal of Medical Genetics, 1983
- Parental asthma, parental eczema and asthma and eczema in early childhoodJournal of Chronic Diseases, 1983
- A Genetic Study of Total IgE Levels in the AmishHuman Heredity, 1982
- The Epidemiology and Genetics of Atopic AllergyNew England Journal of Medicine, 1981
- Genetic transmission of serum IgE levelsAmerican Journal of Medical Genetics, 1981
- Genetics of human immune response to allergensJournal of Allergy and Clinical Immunology, 1980
- RAISED LEVELS OF A NEW IMMUNOGLOBULIN CLASS (IgND) IN ASTHMAThe Lancet, 1967
- THE INHERITANCE OF ALLERGIC DISEASEAnnals of Eugenics, 1936