A double-blind trial of ibuprofen (Brufen) and aspirin was carried out in 60 soft-tissue injuries to the lower limb in a small group of rigorously supervised professional footballers. Ibuprofen significantly reduced the period and severity of pain (p<0.01) and allowed training on average two days earlier than the controls taking aspirin (p<0.001). Players were also able to reach match fitness earlier with ibuprofen (p<0.01). The possible action and use of anti-inflammatory agents given immediately after soft-tissue trauma are discussed.