Leflunomide Inhibits Pyrimidine de Novo Synthesis in Mitogen-stimulated T-lymphocytes from Healthy Humans
- 1 August 1998
- journal article
- Published by Elsevier in Journal of Biological Chemistry
- Vol. 273 (34), 21682-21691
- https://doi.org/10.1074/jbc.273.34.21682
Abstract
No abstract availableKeywords
This publication has 37 references indexed in Scilit:
- From Bench Top to BedsideScience, 1997
- REGULATION OF B CELL FUNCTION BY THE IMMUNOSUPPRESSIVE AGENT LEFLUNOMIDE1Transplantation, 1996
- Dihydroorotate Dehydrogenase Is a High Affinity Binding Protein for A77 1726 and Mediator of a Range of Biological Effects of the Immunomodulatory CompoundJournal of Biological Chemistry, 1995
- Leflunomide, a reversible inhibitor of pyrimidine biosynthesis?Inflammation Research, 1995
- Leflunomide interferes with pyrimidine nucleotide biosynthesisInflammation Research, 1995
- Inhibition of Interleukin 2 (IL-2)-stimulated tyrosine kinase activity by leflunomideInflammation Research, 1994
- Inhibition of the epidermal growth factor receptor tyrosine kinase activity by leflunomideFEBS Letters, 1993
- Deoxyribocytidine Is Salvaged Not Only into DNA but Also into Phospholipid Precursors.: IV. Exogenous Deoxyribocytidine Can Be Used with the Same Efficacy as (Ribo)cytidine for Lipid ActivationBiochemical and Biophysical Research Communications, 1993
- Leflunomide (HWA 486), a novel immunomodulating compound for the treatment of autoimmune disorders and reactions leading to transplantation rejectionInflammation Research, 1991
- Inhibition of mannose incorporation into glycoproteins and dolichol-linked intermediates of sarcoma 180 cells by 6-methylmercaptopurine ribonucleosideInternational Journal of Cancer, 1987