Tooth Crown Morphogenesis and Cytodifferentiations: Candid Questions and Critical Comments

Abstract

Teeth are probably meristic units and crown morphogenesis leads to tooth specific distribution of functional cells. Since heterodonty is derived from homodonty, one way to understand tooth morphogenesis would be to unravel the involved phenomena in homodont species and then to characterize the “put up job” of evolution leading to species specific dentitions with particular functional abilities. Interaction of paleontologists and developmental biologists should be initiated. My naive “developmental” point of view will illustrate only one facet of mouse tooth morphogenesis and cytodifferentiation. The main concern will be to try to discriminate between known facts and speculations, between hypotheses and anticipated or deduced certitudes, to call attention to conflicting data, to suggest some further investigations and to advocate the point of view that molecular interpretations should be founded on indisputable morphological data.