Bidirectional regulation of cAMP generating system by dopamine-D1 and D2-receptors in the rat retina
- 1 October 1990
- journal article
- research article
- Published by Springer Nature in Journal of Neural Transmission
- Vol. 81 (3), 235-240
- https://doi.org/10.1007/bf01245045
Abstract
Accumulation or inhibition of cAMP formation in response to dopamine or dopamine related drugs in the absence or in the presence of forskolin and/or IBMX was investigated in isolated rat retina. While the existence of D1-receptors (positively coupled with adenylate cyclase) was confirmed, D2-receptors (negatively coupled to adenylate cyclase) were also revealed by using a selective D1-antagonist (SCH 23390), a D2-agonist (LY 171555) or two D2)-antagonists (S-sulpiride, spiroperidol). These results indicate that rat retina may be used for the study of both types of dopamine-receptors.Keywords
This publication has 9 references indexed in Scilit:
- LIGHT MODULATES DOPAMINE-REGULATED WALSH INHIBITOR ACTIVITY AND DOPAMINE-DEPENDENT CYCLIC-AMP ACCUMULATION IN THE RABBIT RETINA1990
- Involvement of D1 and D2 Dopamine Receptors in the Control of Horizontal Cell Electrical Coupling in the Turtle RetinaEuropean Journal of Neuroscience, 1989
- PHARMACOLOGICAL CHARACTERIZATION OF RAT RETINAL DOPAMINE-RECEPTORS1989
- Dopamine: a retinal neuromodulator?Trends in Neurosciences, 1986
- Dopaminergic Regulation of Cone Retinomotor Movement in Isolated Teleost Retinas: I. Induction of Cone Contraction Is Mediated by D2 ReceptorsJournal of Neurochemistry, 1986
- Evidence for a D2 dopamine receptor in frog retina that decreases cyclic AMP accumulation and serotonin N-acetyl transferase activityLife Sciences, 1986
- PHARMACOLOGICAL DIFFERENCES BETWEEN THE D-2 AUTORECEPTOR AND THE D-1 DOPAMINE RECEPTOR IN RABBIT RETINA1985
- Two dopamine receptors: Biochemistry, physiology and pharmacologyLife Sciences, 1984
- A simple and sensitive saturation assay method for the measurement of adenosine 3′:5′-cyclic monophosphateBiochemical Journal, 1971